Memophenol™ is the only product your memory will really remember.

Memophenol trust your memory

Memophenol™ is an innovative solution created for memory supplements.
It combines the synergistic activities of French grape (Vitis vinifera) and wild blueberry (Vacciunium angustifolium) extracts.

Memophenol™ has been demonstrated to:

Promote learning

Support working memory

Improve long-term memory

What makes Memophenol™ special?

In the past decade, several large-scale epidemiological studies underlined that people consuming high content of flavonoids showed less cognitive decline than people having a low flavonoid intake, either in Europe, North-America and Japan.

All flavonoids are not equivalent: the smaller, the better. Only bioavailable flavonoids, including specific catechins (monomers of flavanols), flavonols and anthocyanins, have been demonstrated to have a positive impact on cognitive function, at contrary to less-bioavailable flavonoids, such as polymers and tannins.

Inspired by these epidemiological studies, Activ’Inside promoted the creation of an international collaborative program bringing together memory and nutrition sciences: the Neurophenol™ Consortium. Based on a pharmaceutical approach, four years of research have substantiated the high bioavailability, the strong mechanism of action and the cognitive effects of Memophenol.

Neurophenols project

How does it works?

A complete mechanism of action on brain

Memophenol metabolites cross the blood brain barrier to reach their target organ: the brain. In there, they act on 2 main parameters involved in the normal functioning of learning and memory:

Neurons network_IconMemophenol™ improves neurogenesis

by increasing the quality of newborn neurons.

Memophenol boosts the expression of Calmodulin dependent protein kinase II, as demonstrated in the hippocampus of mice brain.

Memophenol™ supports neurons communication

by positively modulating key protein

involved in synaptic plasticity

Memophenol™ boosts the expression of Nerve Growth Factor (NGF), as demonstrated in the hippocampus of mice brain.

The memory function

When we receive information, they are first stored in the short-term memory, also called working memory. Thanks to learning, they can be saved in the long-term memory. The hippocampus, key-region of the brain involved in learning and retrieval of memory, worsens with age and leads to cognitive impairments.

memory function

Did you know?

Neurophenol™ Consortium includes 10 industrial and academic partenaires such as NutriNeuro (University of Bordeaux/INRA, France), Laval University (Canada), INRS (Canada) and Oniris (France).

Neurophenol website
Neurophenol logo

Memophenol™ has shown to have:

Synergistic action

Bioavailable ingredients

Complete action

Pre-clinical results

A patent-pending synergistic solution

A patent-pending synergistic solutionFour blueberry active compounds, (quercetin glucuronide, chlorogenic acid, petunidin-3-glucoside and malvidin-3-glucoside) have shown, when administered in mice at the same dosage, to be on average three to six times more absorbed when combined with grape monomers of flavanols.

A bioavailable solution

More than 30 Memophenol phenolic metabolites have been identified and quantified in animal plasma. Some of them, including catechin and ferulic acid, were measured in mice brain, hence demonstrating a high bioavaibility.

Memophenol improves spatial learning and memory, in mice

Graph spatial learning

In the Morris water maze test, mice fed with Memophenol improve their spatial learning and memory at any age, compared to mice without Memophenol. The improvement reached 20% in aged mice group.
Memophenol restores aged mice abilities to the adult mice level.

Bensalem et al., 2016

Memophenol improves learning, short-term and long-term memories.

Clinical results on seniors

Memophenol™ has been evaluated on more than 200 people during 6 months in a
bicenter, randomized, double-bind and placebo-controlled clinical study.

215 subjects, Aged 60 to 70

300 mg twice daily

6 months

CANTAB: a test battery from Cambridge cognition

Cognitive validated tests from Cambridge Cognition have been used to assess learning and memory performances at the beginning and at the end of the clinical study.

This test battery has been also used to assess the effects of docosahexaenoic acid on cognition.

Cantab test pal

CANTAB tests VRM

Memophenol improves verbal working memory (Short-term)

60 more words recalled

During the Verbal Recognition Memory Free Recall test, people supplemented for 6 months with Memophenol™ recalled 2.5 times more words than people without supplementation (change from baseline).

 

This represents an improvement of about 60% with Memophenol™

(57%, p=0.006)

Less memory loss with Memophenol™ (long-term)

With Memophenol™, subjects having the lowest score at baseline (total errors>57) made 2.5 times less errors on the Paired Associates Learning (PAL) test, compared to those supplemented with the placebo. (p=0.037)

Rejuvenate your memory with Memophenol™

10 years cognitive age

After 6 months of supplementation, results obtained on subjects having the lowest score on PAL at baseline have shown an improvement of cognitive age, compared to placebo (n=47, total errors>57).

 

Memophenol™ allows similar memory performances of 8 years younger people.

Post-hoc estimation of the theoretical cognitive age based on normative data obtained from the CANTAB on the Paired Associates Learning test. Supplemented people having between 70-80 years old show results equivalent to people of 60-70 years old.

Proprietary results on students

More and more concerned by information and work overloads, students look for natural solutions aiming to boost their cognitive performances.

 

A new consumer study performed by Activ’Inside highlights that MemophenolTM boosts student’s cognitive performances in 15 days only.

Effects are amplified after 30 days:

2 out of 3 students have better concentration capacities

3 out of 5 students feel an improvement of their memory, learning & intellectual performances

MemophenolTM is recommended by 3 out of 4 students

Memophenol is the only product your memory will really remember.

Awards

Two awards recognize true innovation, cutting edge research and strong scientific background
supporting the effectiveness of Memophenol™
.

 

 

winner nutra ingredients awards 2017

Memophenol™ has been rewarded as the Ingredient of the year, in the Healthy Ageing category, at NutraIngredients Awards 2017.

Memophenol™ has been rewarded as the best Pharmaceutical Product in the 2016 French Innovation Corner contest.

Contact us

Activ'inside
ACTIV’INSIDE
ZA du Grand Cazau,
33750 Beychac & Caillau,
Bordeaux Area, France

05.35.54.15.60
www.activinside.com