Memophenol™ is an innovative solution created for memory supplements.
It combines the synergistic activities of French grape (Vitis vinifera) and wild blueberry (Vacciunium angustifolium) extracts.
Memophenol™ has been demonstrated to:
In the past decade, several large-scale epidemiological studies underlined that people consuming high content of flavonoids showed less cognitive decline than people having a low flavonoid intake, either in Europe, North-America and Japan.
All flavonoids are not equivalent: the smaller, the better. Only bioavailable flavonoids, including specific catechins (monomers of flavanols), flavonols and anthocyanins, have been demonstrated to have a positive impact on cognitive function, at contrary to less-bioavailable flavonoids, such as polymers and tannins.
Inspired by these epidemiological studies, Activ’Inside promoted the creation of an international collaborative program bringing together memory and nutrition sciences: the Neurophenol™ Consortium. Based on a pharmaceutical approach, four years of research have substantiated the high bioavailability, the strong mechanism of action and the cognitive effects of Memophenol™.
Memophenol™ metabolites cross the blood brain barrier to reach their target organ: the brain. In there, they act on 2 main parameters involved in the normal functioning of learning and memory:
by increasing the quality of newborn neurons.
by positively modulating key protein
involved in synaptic plasticity
When we receive information, they are first stored in the short-term memory, also called working memory. Thanks to learning, they can be saved in the long-term memory. The hippocampus, key-region of the brain involved in learning and retrieval of memory, worsens with age and leads to cognitive impairments.
Neurophenol™ Consortium includes 10 industrial and academic partenaires such as NutriNeuro (University of Bordeaux/INRA, France), Laval University (Canada), INRS (Canada) and Oniris (France).
Memophenol™ has shown to have:
Four blueberry active compounds, (quercetin glucuronide, chlorogenic acid, petunidin-3-glucoside and malvidin-3-glucoside) have shown, when administered in mice at the same dosage, to be on average three to six times more absorbed when combined with grape monomers of flavanols.
More than 30 Memophenol™ phenolic metabolites have been identified and quantified in animal plasma. Some of them, including catechin and ferulic acid, were measured in mice brain, hence demonstrating a high bioavaibility.
In the Morris water maze test, mice fed with Memophenol™ improve their spatial learning and memory at any age, compared to mice without Memophenol™. The improvement reached 20% in aged mice group.
Memophenol™ restores aged mice abilities to the adult mice level.
Memophenol™ improves learning, short-term and long-term memories.
Memophenol™ has been evaluated on more than 200 people during 6 months in a
bicenter, randomized, double-bind and placebo-controlled clinical study.
Cognitive validated tests from Cambridge Cognition have been used to assess learning and memory performances at the beginning and at the end of the clinical study.
This test battery has been also used to assess the effects of docosahexaenoic acid on cognition.
During the Verbal Recognition Memory Free Recall test, people supplemented for 6 months with Memophenol™ recalled 2.5 times more words than people without supplementation (change from baseline).
This represents an improvement of about 60% with Memophenol™
With Memophenol™, subjects having the lowest score at baseline (total errors>57) made 2.5 times less errors on the Paired Associates Learning (PAL) test, compared to those supplemented with the placebo. (p=0.037)
After 6 months of supplementation, results obtained on subjects having the lowest score on PAL at baseline have shown an improvement of cognitive age, compared to placebo (n=47, total errors>57).
Memophenol™ allows similar memory performances of 8 years younger people.
Post-hoc estimation of the theoretical cognitive age based on normative data obtained from the CANTAB on the Paired Associates Learning test. Supplemented people having between 70-80 years old show results equivalent to people of 60-70 years old.
More and more concerned by information and work overloads, students look for natural solutions aiming to boost their cognitive performances.
A new consumer study performed by Activ’Inside highlights that MemophenolTM boosts student’s cognitive performances in 15 days only.
Effects are amplified after 30 days:
Memophenol™ is the only product your memory will really remember.
Two awards recognize true innovation, cutting edge research and strong scientific background
supporting the effectiveness of Memophenol™.
Memophenol™ has been rewarded as the Ingredient of the year, in the Healthy Ageing category, at NutraIngredients Awards 2017.
Memophenol™ has been rewarded as the best Pharmaceutical Product in the 2016 French Innovation Corner contest.